As a writer, Kelly’s animated short Message in a Bottle premiered on Adult Swim in 2021, and her animated digital series The Duchess of Nothing premiered on Adult Swim in 2023. Her short film Sativa, which she wrote, co-directed and starred in premiered on Eternal Family and NoBudge in 2022, garnering a writeup in Vulture. Her other short film Delivery, which she co-wrote and starred in, was featured on NoBudge, and her film Landlady was a selection at the Austin and Portland comedy film festivals. She also frequently writes for the popular Buzzfeed cartoon The Land of Boggs. Her comedy group Ladies Who ranch sold a pilot to Paramount, which she is co-writing and co-executive producing alongside Sophie Zucker (The Daily Show) and Katie Rich (Harley Quinn). The show is produced by Michael Melamedoff (Cowboy Bear Ninja).

As an actor, Kelly is a frequent sketch performer on The Tonight Show with Jimmy Fallon, and has also appeared in a sketch for The Daily Show. She has starred in a number of commercials, including ones for Mountain Dew and Rula. Kelly appeared in the 2025 TriBeCa film The Scout, co-starred in the 2022 Slamdance audience award winner Yelling Fire in an Empty Theater (Cinedigm), starred in several short films on NoBudge, and has worked as voice over actress on several Adult Swim cartoons (The Duchess of Nothing, Dewdge Center, Squatters).

As a performer, she’s had shows previewed in Time Out New York and The New York Times, like her show The Dramedians, a play she co-wrote and co-starred in with Maya Sharma. She also performers improv and sketch comedy with Ladies Who Ranch in New York, LA, and Chicago.